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In addition, methylation also keeps certain genes from turning on

In a follow-up study, the same group demonstrated that HPDL deficiency induces a lethal form of mitochondrial encephalopathy and, importantly, supplementation with HPDL-derived intermediates (4-HMA or 4-HB) was sufficient to alleviate disease symptoms

It was found that 48-h exposure to rotenone significantly increased Ca 2+ content, indicated by Fluo3(i) fluorescence, and increased ceramide content, decreased cell size measured as FSC, and increased annexin V binding

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doi:10.1136/bmjopen-2014-006964

Associated Press (AP)