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The hydroxyl group in the chromanol head of -tocopherol donates a hydrogen atom to neutralize lipid peroxyl radicals, halting their propagation in membranes and circulating lipoproteins

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While polygenic risk scores (PRS) address part of this architecture by aggregating validated risk alleles from GWAS, the proposed workflow further considers the potential cumulative burden of variants typically deemed benign, aiming to bridge the gap between population-level risk estimation and individualized interpretation (Torkamani et al., 2018)

[PubMed] [Google Scholar] Aoyama K