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Based on studies suggesting people taking a glucagon-like peptide-1 (GLP-1) could be less likely to develop Alzheimers, Novo Nordisk set up two large trials of its drug, semaglutide sold as the popular diabetes and obesity drugs Ozempic and Wegovy

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Combining glucagon-like peptide 1 receptor agonists and sodiumglucose cotransporter 2 inhibitors to target multiple organ defects in type 2 diabetes

The mechanism appears to involve altered dopamine signaling in brain reward pathways

The STEP 5 trial showed continued loss out to 104 weeks in some participants