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Every Other Day (EOD) Dosing Every other day dosing at slightly higher per-session amounts (e.g., 23 mg EOD instead of 1 mg daily) is also used, particularly to reduce injection frequency or manage cost

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Selenium: This mineral is a key component of glutathione peroxidase, an enzyme that allows glutathione to neutralize hydrogen peroxide

IGF-1 signaling is also responsible for hyperalgesia [169]

In pancreatic cancer, DON treatment reduces the levels of hyaluronic acid and collagen, resulting in extensive remodeling of the extracellular matrix (ECM) surrounding the tumor [183]

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