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Early trials on small number of subjects during the late 1950s showed the benefits of higher doses, though they did not consider their metabolic effects (Beyer et al., 1957

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That fundamental research research like the kind Richard DiMarchi conducts has to come from laboratories at universities, smaller companies and startups. When the chemistry department recruited DiMarchi, he insisted his lab be in Bloomington, even though it initially required travel from his primary residence in Carmel, Indiana, because at the core I am a chemist, and the chemistry department at Indiana University Bloomington is world-class. Clemmer, who was chair of the department when DiMarchi joined, said he was able to recruit DiMarchi because of the opportunity to collaborate with the departments visionary researchers and access other leading academic researchers like German physician Matthias Tschp, a key player in the refinement of GLP-1 drugs for obesity treatment

however, they are not always indicative of the disease