First, is your composition-of-matter claim narrow enough to survive a post-grant opposition from a large-pharma competitor with an overlapping estate, and broad enough to cover the follow-on molecules you are likely to generate over the next ten years
The Evolving Diabetes Treatment Landscape The current American Diabetes Association (ADA) and European Association for the Study of Diabetes (EASD) approved algorithm for the treatment of T2DM is illustrated in FIGURE 1
doi: 10.1016/j.lfs.2020.118966 195 PetitJMVergsB
Some people continue to experience mild appetite changes long-term, which is actually part of how the medication supports weight management
Rapid weight changes often stretch the abdominal wall, leading to a separation of the core muscles known clinically as diastasis recti
In one animal study, gymnema caused a 2.4-fold increase in the clearance of tolbutamide, a CYP2C9 substrate, in rats