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Forsythia suspensa (forsythia), a key botanical in the traditional Chinese formula BaoHeWan, is a widely distributed deciduous shrub and a fundamental component of Chinese medicine

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Cells with impaired PERK-eIF2a-ATF4 signal transduction are more sensitive to hypoxic stress in vitro , indicating that the PERK-eIF2a-ATF4 pathway provides a survival advantage for cells under hypoxic conditions (75, 76), which is crucial for resistance to intracellular hypoxia, metabolic stress, and starvation