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Most side effects are gastrointestinal and occur during the early weeks of treatment or when the dose is increased

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Stockwell laboratory in 2012, represents an iron-dependent, non-apoptotic cell death modality distinguished by intracellular iron accumulation and lipid peroxidation, culminating in cell membrane disruption and cellular demise ( Disrupted iron homeostasis constitutes a primary trigger for ferroptosis initiation

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Yin M, Sillje HH, Meissner M, van Gilst WH, de Boer RA