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B12 deficiency is associated with psychiatric symptoms including depression, irritability, and cognitive impairment, but not excess intake

F.ShenY

Again, human time-course data is absent, so the following is informed inference from peptide pharmacology and animal work rather than measured human curves

DOI: 10.1002/9780470744307.gat166

Finally, although the correlations between the metabolome and microbiome were established using robust statistical analyses, there was limited statistical power and there are also limitations to the statistical approaches used herein (e.g., log transformation to resolve non-normal distribution and/or heteroscedasticity 103 )