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Google Trends data for "Ozempic" spiked in late 2022, and off-label semaglutide prescriptions for weight loss increased substantially during this period, contributing to supply shortages that affected patients with type 2 diabetes who depended on the medication

Lifestyle choices influence fertility, with evidence linking alcohol, obesity, and smoking to poor semen quality and ovulatory function

However, it is not approved for use in children or adolescents

This integrated approach optimizes both treatment safety and clinical outcomes

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The STEP trials, which followed over 4,500 participants, showed that semaglutide combined with lifestyle modifications resulted in weight loss ranging from 10% to 22% of body weight depending on the dose used