Leptin, which tells your body when youre full Ghrelin, which has been dubbed the hunger hormone As you eat, your gut releases other hormones, such as GLP-1 and peptide YY (PYY)
ACS Pharmacology & Translational Science, 4(1), 296313
For a foundational overview of peptide biology, see What Are Peptides
Further research is needed but it is known that combination therapies with GLP-1s and other compounds, such as Glucagon which has potent effects on fat and increased energy expenditure, may be utilized to reset the metabolism to a point where GLP-1s may not need to be taken as frequently
This helps your body adjust, so full effects may not be noticeable until your second month
Smaller retrospective studies those that look back in time suggest that there are benefits to using GLP-1 medications with type 1 diabetes