The deformability of RBCs is governed by three primary determinants: (1) the surface-area-to-volume ratio of the cell, (2) the viscoelastic properties of the membrane (determined by the spectrin-based cytoskeleton and lipid bilayer), and (3) the cytoplasmic viscosity (largely influenced by hemoglobin concentration and composition) [1] [2]
An exploration of the functional significance of several SNPs in the gene for cystathione lyase associated with autistic disorder may shed light on this putative relationship [94]
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