Previous Treatment History and Medication Response Patterns Patients who have failed conventional weight loss methodscalorie restriction, exercise, or previous pharmacotherapy with orlistat or phentermineoften respond exceptionally well to GLP-1 agonists
18 REWIND was a randomised controlled trial of the long-acting GLP-1RA dulaglutide versus placebo in 9,901 people with type 2 diabetes
[DOI] [PMC free article] [PubMed] [Google Scholar] 50.Montagne A, Barnes SR, Sweeney MD, Halliday MR, Sagare AP, Zhao Z
Together with studies in rodents, these translational findings support further exploration of LAC as a therapeutic target that may help to define individualized treatments in biologically based depression subtype consistent with the spirit of precision medicine.
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