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The HCV FAD-capping frequency is around 75%, which is the highest observed for any RNA metabolite cap across all kingdoms of life 4,5,6,7,8

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In rats with STZ-induced cognitive impairment, mitochondrial dysfunction was increased with alterations in activities of NADH dehydrogenase, succinate dehydrogenase, and cytochrome oxidase enzyme complexes

Last but not least, GSH participates in non-enzymatic conjugation with some chemicals, for instance, it is hypothesized that glutathione reacts with n-acetyl-p-benzoquinone imine (NAPQI) -the cytochrome P450 reactive metabolite formed by toxic overdose of acetaminophen- to detoxify it.