semaglutide naion use in patients with diabetes was associated with an increased risk of nonarteritic anterior ischemic optic neuropathy (NAION) at 2, 3, and 4 years. https://ja.ma/4iZkMeV Smaller NAION Risk with Semaglutide

The name comes from its original discovery context, the compound was first isolated from the brains of rabbits during electrically induced delta wave sleep

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It also modulates the nitric-oxide system, promoting nitric-oxide production in a dose-dependent way and countering agents that block the pathway [5]

This applies especially when using it for injections or medication preparation

Interestingly, the benefit of liraglutide for tau phosphorylation in diabetic mice cannot be replicated by insulin treatment, suggesting that the unique neuroprotective effects of GLP-1RAs are medicated by pathways other than insulin signaling pathways [62]