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Helv Paediatr Acta

lowest tolerated dose Phase Step 2 Weeks Weeks 5-8 Cagrilintide Dose 0.5 mg/week Purpose Dose escalation Phase Step 3 Weeks Weeks 9-12 Cagrilintide Dose 1.0 mg/week Purpose GI side effects often peak here Phase Step 4 Weeks Weeks 13-16 Cagrilintide Dose 1.7 mg/week Purpose Approaching maintenance Phase Maintenance Weeks Weeks 17+ Cagrilintide Dose 2.4 mg/week Purpose Target dose used in late-stage study protocols Each step lasts 4 weeks

Gabbard, MD, FACG, Cleveland Clinic and Milli Gupta, MD, University of Calgary Updated May 2024

Chronic multisymptom illness affecting Air Force veterans of the Gulf War

Free radicals are molecular entities containing at least one unpaired electron

Tyramine does not cross the blood-brain-barrier (Bertler et al, 1966