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Thus, cystine and GSH regulate the transcriptional program of the ISR in an interdependent manner in HepG2 cells

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Available at: Younossi ZM, Kalligeros M, Henry L

It affects over 50% of men by the age of 50 and typically manifests in the temples, vertex, and mid-frontal scalp region[1]

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It typically begins after the age of 30, at a rate of 0.1% to 0.5% annually, and accelerates beyond the age of 65 due to physiological and metabolic changes in aging populations