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Kim BJ, Sung KC, Kim BS, Kang JH, Lee KB, Kim H, Lee MH

Orforglipron is a small-molecule GLP-1, allowing it to be dosed without regard to meals, an attribute that may offer a competitive advantage in this category

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Therapeutic strategies targeting glutamine metabolismsuch as the antagonist DON, combined with glycolytic inhibitor 2-DG or metformincan suppress effector T cell responses, though the effects of glutamate supplementation may vary depending on the pathological context, necessitating tailored approaches (120, 121)

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