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DCCT sub-analyses established that glycemic variability (not just HbA1c) predicts diabetic complication risk, making pramlintide's variability-reducing effects potentially more clinically important than the modest HbA1c change alone

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ACR Open Rheumatol 5(5):464-469, 2022

Some people taking tirzepatide have reported body aches, muscle pain, or joint discomfort

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