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Within the brain, DSIP is particularly abundant in the hypothalamus, hippocampus, and limbic regions, where it interacts with multiple peptide and non-peptide mediators, including corticotropin-like intermediate peptide (CLIP), adrenocorticotrophic hormone (ACTH), melanocyte-stimulating hormone (MSH), and melanin-concentrating hormone (MCH)

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Ac-SDKP retains the beneficial properties of T4 and is orally bioavailable in enteric-coated capsule form

Using the social isolation with chronic restraint rat model, we confirmed that trimetazidine (30 mg/kg) injected once-daily for 2 weeks had an antidepressant-like effect shown by reduced immobility in the forced swim test

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