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Emerging concerns include: Risks of micronutrient deficiencies caused by very low food intake

Advances in receptor de-orphanization, including functional genomics and computational ligandreceptor matching, may ultimately unlock METRNLs full therapeutic potential

New Hampshire Medicaid removed coverage effective January 1, 2026, citing these medications as a significant cost driver. 12,13 Pennsylvania Medicaid removed coverage effective January 1, 2026

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Dehydration represents an under-discussed risk factor with both therapies, as reduced appetite and occasional vomiting can decrease fluid intake

Certain medical issues may pose some additional risk factors