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NASH caused hepatomegaly, fibrosis, and inflammation in all mice, with aged mice showing increased heart weight, left ventricular volumes, and subtle systolic and diastolic dysfunction, thus NASH tends to worsen age-related cardiac dysfunction [37]

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Therefore, the decrease of serum secondary BAs upon HZRG treatment indicated lower reabsorption from the intestine, which was consistent with the alteration of fecal BA concentrations

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The life value of GSH makes for a paramount research field in biology and medicine and may be key against SARS-CoV-2 infection and COVID-19 disease