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Metformin has shown greater efficacy in CSC populations with low glutaminolysis, whereas resistance is often observed in glutamine-addicted cellsa limitation that can be mitigated through cotargeting glutamine metabolism

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doi:10.1016/S0014-5793(03)01043-3

A lack of MTFT induces mitophagy in osteoblasts through the ROS/PINK1/Parkin pathway to release iron, but excess the iron cannot be stored through the MTFT pathway, gradually accumulates and ultimately induces ferroptosis in osteoblasts [266]

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10.1016/j.fm.2015.04.002 Food Microbiol