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The dual GIP/GLP-1 approach is what set tirzepatide apart from the earlier single-target GLP-1 agonists

The most commonly reported side effects were gastrointestinal issues such as nausea, vomiting, and diarrhea

Yet, in practice, these protein levels are likely difficult to achieve in a population of GLP-1 RA users who have 1) a higher body mass and 2) a reduced energy intake

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Another difference is convenience

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