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The primary outcome will be the percentage of participants with 3 step Early Treatment Diabetic Retinopathy Study (ETDRS) subject-level progression at five years, as well as secondary outcomes including 17 ocular and four systemic outcomes

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81 NAD + and NAMPT levels in neural tissues are reduced with age, and NAD replenishment reduces the severity of ataxia telangiectasia neuropathology, restoring neuromuscular function and memory loss that accompany aging processes

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192 (2): e319

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