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Interestingly, global IGF-I KO, Cart IGF-IR / , and TamCar IGF-IR / mice all show increased expression of PTHrP protein and RNA, but decreased Ihh expression in their growth plates, indicating a disrupted PTHrP/Ihh feedback loop (26,32)

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doi: 10.3389/fnins.2022.833630, 104 RanT.ShenY.PengD.TangL.PanZ.ZengX.et al

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