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Control of immune-mediated dermatological disorders
Emerg Infect Dis 2011;17(2):173179
Specifically, under the stimulation of DNA damage, p53 is activated and its target genes p21 Waf1/Cip1 and Bax-1 are inhibited, and suppression of p21 Waf1/Cip1 towards cyclin-CDK and proliferating cellular nuclear antigen (PCNA) is diminished, thereby activating the cell cycle
Other drugs, such as monoamine oxidase B (MAO-B) inhibitors (e.g., rasagiline, safinamide, selegiline) or catechol-O-methyltransferase (COMT) inhibitors (e.g., entacapone, tolcapone), may also be used to improve dopamine levels, although sometimes symptoms may persist or worsen even with optimized dopaminergic therapy (Pardo-Moreno et al., 2023
PMCID: PMC6812410
10.3390/metabo14010073 85
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