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Rotate zones with each weekly injection

Patients with genetic predispositions toward strong GLP-1 pathway activation may achieve target outcomes at lower doses, while those with less responsive pathways might benefit from extended time at higher therapeutic levels

Group comparisons of these rates were first assessed with Students t -tests (two-sided) for an initial view

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In addition, one must gain FDA approval by clinically demonstrating that the delivery of the microbe-encapsulated GLP-1 through this oral route leaves the drug molecule itself unchanged (with no post-translational modifications), that it has a similar pharmacokinetic profile to the reference molecule, and that it shows no adverse effects