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These analogs allosterically mimic dimerization/activation, a prerequisite to binding to the Type 1 tyrosine kinase receptor c-Met [29,30]

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Subsecuentemente, la activacin de vas de sealizacin secundarias, incluyendo protena quinasa A (PKA) y Epac2, alteran la actividad de los canales de iones celulares, causando niveles elevados de calcio citoslico que aumentan la exocitosis de grnulos contenedores de insulina

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