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Finally, at 24 months, the MD was 1.42 (95% CI: 2.43, 0.41) with 54% heterogeneity ( I 2 ) and a p -value of 0.002
Common side effects reported in trials include: Nausea (the most frequently reported) Vomiting Diarrhoea Constipation Decreased appetite Abdominal discomfort or bloating These effects are largely attributable to the drug's actions on gastric emptying and gut motility
Alex Azar, former Secretary of the US Department of Health and Human Services, noted that there is little stigma around taking a statin to manage high cholesterol, but using a GLP-1 to help with weight loss can be perceived by some as taking the easy way out. Panelists emphasized that this perception, despite its inaccuracy, persists and may stand in the way of patients accessing these effective treatments or staying on them long-term
When would lipase testing be appropriate
Nonetheless, these patients should be counselled about recognising allergic symptoms
If these oral small molecule drugs can match their larger cousins, they may solve the problem of the difficult mass production of peptide drugs
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