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However, in the presence of oxidative or nitrosative stress, GST can form homodimers that alter the reduced states of cysteine residues in its structure, resulting in JNK dissociation from the GSTJNK heterocomplex and causing subsequent activation of the c-Jun protein

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Most clinical studies assess outcomes at 24 weeks, with continued improvement typically observed through 12 to 24 months of use

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