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Patients can present as heterozygotes with only one gene encoding for an abnormal enzyme, or as a homozygote with both genes encoding for the defective enzyme

Emerging roles of endoplasmic reticulum-resident selenoproteins in the regulation of cellular stress responses and the implications for metabolic disease

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These especially include narcotic and anticholinergic agents (including antidepressants)

Regular Monitoring for Recurring Skin Reactions One of the most important steps in managing a semaglutide-induced rash is regular monitoring

Clinical Scenarios of Interest To address further practical considerations, four clinical scenarios are described that are aimed at providing clues for the better management of GI AEs in those patients at higher risk of these complications that are going to undergo GLP-1 RA-based therapy (Table 4)