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Busetto L, Bettini S, Makaronidis J, et al

Animal Model:8-10 male C57BL/6J mice [1] Dosage:50 mg/kg Administration:i.p., a single dose for 28 or 12 days Result:Displayed a more oxidative muscle phenotype, increased the complex I (NDUFB8) and complex V (ATP5A) protein expression in the gastrocnemius muscle and cytochrome C, mitochondria content and oxidative type IIa muscle fibers lavels in mice

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More studies need to be conducted to test whether repeated dosing could help the drug penetrate further over time