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Other significant safety considerations include a history of pancreatitis, acute kidney injury risk, diabetic retinopathy complications in patients with type 2 diabetes, gallbladder disease, hypoglycemia risk in patients using other diabetes medications, and mental health monitoring for mood changes or suicidal ideation

While STEP-HFpEF was underpowered to truly detect outcome differences, the difference observed supports the need for larger, outcomes-driven trials in obese patients with HFpEF

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Key Takeaway: Clinical studies indicate that tirzepatide often leads to a measurable decrease in blood pressure as a result of significant weight loss

Tirzepatide simply makes that process easier by improving satiety and insulin sensitivity