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reported that after 18 months of CR, the trabecular bone score at the hip decreased by 0.22%, while cortical thickness declined by 2.45%

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For patients with mild renal insufficiency: (creatinine clearance [CrCl] 50 mL/min, approximately corresponding to serum creatinine levels of 1 Concomitant Use with an Insulin Secretagogue (e.g., Sulfonylurea) or with Insulin : When JANUVIA is used in combination with an insulin secretagogue (e.g., sulfonylurea) or with insulin, a lower dose of the insulin secretagogue or insulin may be required to reduce the risk of hypoglycemia

And that I think what explains that is just the vicious cycle of the mitochondria got, they lost a quarter percent here or a quarter percent there, and they just started repairing themselves less effectively because theyre the engines fueling everything, including that

Harvard Health provides a clear overview of these mechanisms