343 Evexomostat (SDX-7320), which irreversibly binds METAP2 and regulates insulin, leptin, and adiponectin downstream, was one of the first drugs developed for cancer patients with metabolic complications
There was no effect of sex ( p = 0.321
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While IGF1 LR3 itself is not carcinogenic, the growth-promoting effects of IGF-1 signaling raise theoretical concerns about long-term exposure