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Dr James Cream contains Glutathione which acts as an antioxidant against sun damage and inhibits this process of melanogenesis by inhibiting tyrosine kinase, the enzyme that catalyzes melanin production

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Nrf2 is a crucial oxidative-stress-responsive transcription factor that governs the expression of antioxidants and cytoprotective genes, protecting cells against oxidative stress to maintain cellular ROS homeostasis [50]

Kirchgessner TG, Sleph P, Ostrowski J et al (2016) Beneficial and Adverse Effects of an LXR Agonist on Human Lipid and Lipoprotein Metabolism and Circulating Neutrophils