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doi:10.1007/s12325-019-01101-6

Moreover, the upregulation of LDLR gene expression in cells treated with GLP-1RAs occurs through both SREBP-2-dependent and SREBP-2-independent pathways

This is murkier than the old guidance suggested

Cftr potentiators: From bench to bedside

As these agents gain traction not only in individuals with metabolic disease but also in otherwise healthy populations, their clinical reach continues to expand

However, tachyphylaxis (tolerance) develops rapidly within 3-5 days of continuous dosing, food intake returns to baseline levels (Cote et al., 2010)