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The activated Akt signaling pathway activates downstream mTOR via the Akt-mTOR axis to promote protein synthesis, while also inhibiting NF-B and the binding of myostatin promoter, reducing myostatin expression to mitigate muscle atrophy (136-138)

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Following this, the cells were irradiated with US for 2 min, and further incubated for 3 h

A pseudo-ternary phase diagram was established to better interpret the phase stability

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The FDA approved semaglutide for treating type 2 diabetes in 2017