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Ask about prescriber credentials, baseline labs required before prescribing, thyroid screening, cardiovascular assessment, pharmacy partner verification, and follow-up visit frequency

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UK patients should understand that: Available evidence is largely from Phase 2 studies with relatively short follow-up periods Long-term cardiovascular outcome data are not yet available for either agent Phase 3 trials are ongoing, and results will inform future regulatory submissions to the MHRA UK patients interested in accessing these treatments through clinical trials may wish to consult the NIHR 'Be Part of Research' portal (bepartofresearch.nihr.ac.uk) or ClinicalTrials.gov for current recruitment opportunities

Regulation of gamma-glutamylcysteine synthetase subunit gene expression by the transcription factor Nrf2