This includes D-penicillamine (distributed under the brand named including Cuprimine, a capsule, and Depen, a tablet), which was the first oral therapy developed for Wilson disease
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Reports of concerns in pediatric patients are overwhelmingly in the 10-18 age range, and mirror those of adults
Mutat Res 679:1316 Sitta A, Vanzin CS, Biancini GB, Manfredini V, de Oliveira AB, Wayhs CA, Ribas GO, Giugliani L, Schwartz IV, Bohrer D, Garcia SC, Wajner M, Vargas CR (2011) Evidence that L-carnitine and selenium supplementation reduces oxidative stress in phenylketonuric patients
Many people stop taking them because of those side effects and, perhaps even more so, cost and insurance barriers
0.15 oz / 4.5 g