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Estradiol increases stress-induced activation at all levels of the HPA axis, elevating corticotropin-releasing hormone (CRH) and AVP expression in the PVN, POMC mRNA in the pituitary, and ACTH sensitivity in the adrenal glands 80

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Symptoms of NAION The clinical presentation of NAION includes: Loss of upper or lower visual field (altitudinal visual field defects) Relative afferent pupillary defect Swelling of the optic disc with associated bleeding Permanent vision impairment in most cases Risk Factors for NAION Zepbound and Blurry Vision: Risk factors for developing NAION while using Zepbound include: Advanced age (typically over 50 years) Diabetes mellitus High cholesterol levels (hyperlipidemia) Obstructive sleep apnea Anatomical variations such as small optic disc cup-to-disc ratio Zepbound Eye Pain : Recent data on drug safety monitoring suggest that GLP-1 receptor agonists may double the risk of NAION compared to baseline population rates