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Contraindicated in patients with Leber's disease (a hereditary optic neuropathy), as Vitamin B12 may worsen the condition

In both studies, improvements in weight associated with improved quality of life parameters, physical function and cardiometabolic risk factors [47]

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There is a need for clinical guidelines, treatment algorithms and a greater number of validated biomarkers that could help clinicians match nutritional and lifestyle-medicine-based interventions to patients most likely to respond to different interventions

22 The addition of a probiotic (e.g., Lactobacillus GG) may be helpful in some children with functional constipation, although the studies are preliminary