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Bioorganic & Medicinal Chemistry Letters, 2015
Increasing the glucose concentration from 2.8 to 16.7 mM led to a biphasic stimulation of insulin secretion in pancreases of control mice, an effect that was greatly diminished and delayed in Kcnj11 / mice, while basal insulin secretion (at 2.8 mM glucose) was significantly elevated (Figure 1D)
Other safety concerns include risks of pancreatitis, gallbladder disease, and diabetic retinopathy complications (particularly with semaglutide)
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To explore whether VGF expression could increase -cell glucagon secretion, we constructed an adenovirus vector expressing VGF under the control of the glucagon promoter (Supplementary Fig
Olde Damink SW, Deutz NE, Dejong CH, et al
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