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This can be especially problematic in applications where maintaining drug potency and precise delivery timing is crucial, such as cancer therapy or treating infectious diseases

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Given that this condition predominantly affects children, dedicated pediatric registries and long-term studies are essential to address the paucity of data on developmental safety, effects on linear growth and pubertal progression, and long-term cardiometabolic outcomes

Eligible RCTs evaluated tirzepatide or GLP-1RAs and reported major adverse cardiovascular events (MACE), CV mortality, all-cause mortality, non-fatal myocardial infarction (MI) or non-fatal stroke