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The use of prazosin, an 1-adrenergic receptor blocker, showed that the ability of GLP-1RAs to reduce TNF- in plasma was disrupted, signifying the vital role of 1-adrenergic receptors in the anti-inflammatory action of GLP-1RAs
Given that ascites increases intracellular lipid levels and that mono-unsaturated fatty acids (MUFAs) protect against ferroptosis, whereas poly-unsaturated fatty acids (PUFAs) promote it 14 , we sought to determine whether ascites alters the MUFA-PUFA composition of the plasma membrane
Increase if needed within the safe range
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