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After induction of hypertone, a strong positivity to Ub is detected (lane 3), which is significantly reduced in the retina concomitantly treated with carnitine (lane 2)

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These end-states were used to interpret the extreme ranges of heterogeneity present in the particle stack

Affecting approximately 50% of patients with diabetes, DN is predominantly characterized by distal symmetric polyneuropathy, leading to sensory loss, pain, and motor dysfunction, often resulting in diabetic foot ulcers and lower-limb amputations