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The triple receptor agonist works on GLP-1, GIP, and glucagon pathways simultaneously, and that metabolic shift demands adjustment time

Outside the US, Ozempic was completely overtaken by Mounjaro in Q2 2025, dropping from 53% to 41% market share in just one quarter

However, its high retail cost remains a barrier in resource-limited settings, highlighting the need for pricing negotiations and broader insurance coverage to improve accessibility[15]

Real momentum builds during months two through six as doses titrate up and cumulative fat loss becomes visible