This method is considered appropriate if the relative treatment effect can be assumed to be the same across the two trial populations, which was deemed to hold in the populations of SUSTAIN 7 and AWARD-11 (both conducted in people with type 2 diabetes with inadequate glycaemic control on metformin)
Last reviewed: May 23, 2026 Last updated: May 23, 2026 Written by: Jay Hastings, CEO of PlexusDx Jay Hastings is the CEO of PlexusDx, a precision health company focused on genetic testing, blood biomarker insights, and personalized wellness recommendations
The CYP2C9 inhibition discussed above makes this combination genuinely risky
This genotype-dependent efficacy is robustly supported by epidemiological and clinical evidence in colorectal cancer, particularly for individuals with combined GSTM1 and GSTT1 null genotypes
That's where a high-quality protein shake can help you stay consistent, especially on days when appetite is low or meal prep feels difficult
Pressure inside the lower esophageal sphincter (the valve that prevents reflux) decreases under GLP-1 influence, making it easier for acid to escape the stomach
