Kim SY, Yang CS, Lee HM, Kim JK, Kim YS, Kim YR, Kim JS, Kim TS, Yuk JM, Dufour CR, et al
In conclusion, in the tumor environment, excessive ROS accumulation due to mitochondrial abnormalities is a key factor contributing to T cell exhaustion, which not only directly impairs T cell function but also exacerbates T cell exhaustion by interfering with signaling, gene expression, and oxidative stress, forming a vicious cycle and significantly weakening the efficacy of anti-tumor immune responses
Conclusion Whilst severe B12 deficiency has a clear clinical picture with characteristic haematological and/or neurological features, establishing mild or borderline deficiency can be problematic as serum levels are maintained at the expense of tissue concentrations, and therefore serum levels of B12 may be in the low normal or borderline range despite a deficiency
In 2020, medical studies indicated that GLP-1 agonists like Ozempic could exacerbate symptoms of diabetic gastroparesis in patients who already had this condition prior to taking the drug
Prioritize meals that combine protein, fiber, and healthy fats for maximum satiety
10.1016/j.gene.2017.12.029 39